pentobarbital will decrease the extent or effect of ethotoin by impacting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Watch.

pentobarbital will minimize the level or effect of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.

Patients stabilized on corticosteroid therapy may possibly call for dosage changes if barbiturates are included to or withdrawn from their dosage program on account of induction of hepatic microsomal enzymes by barbiturates

fentanyl transmucosal and pentobarbital both of those boost sedation. Steer clear of or Use Alternate Drug. Limit use to people for whom different treatment choices are insufficient

pentobarbital will reduce the extent or outcome of carbamazepine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.

pentobarbital will decrease the level or impact of tipranavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

benzhydrocodone/acetaminophen and pentobarbital both equally maximize sedation. Keep away from or Use Alternate Drug. Limit use to patients for whom choice treatment method solutions are insufficient

pentobarbital will reduce the extent or effect of etravirine by affecting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Keep track of.

pentobarbital will lower the extent or impact of etonogestrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

Therapy must be administered with caution, if whatsoever, to patients that are mentally frustrated, have suicidal tendencies, or history of drug abuse

pentobarbital will decrease the extent or outcome of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Coadministration of fentanyl with CYP3A4 inducers may lead to some decrease in fentanyl plasma concentrations, insufficient efficacy or, possibly, progress of a withdrawal syndrome inside of a affected individual who may have produced Actual physical dependence to fentanyl.

Use another method of contraception or perhaps a backup method when enzyme inducers are applied with merged hormonal contraceptives (CHCs), and continue on backup contraception for 28 days following discontinuing enzyme inducer to be sure contraceptive trustworthiness.

Contraindicated (one)pentobarbital will minimize the extent or result of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is really a delicate CYP3A4 substrate. Coadministration with solid or moderate more info CYP3A4 inducers is contraindicated.

pentobarbital will decrease the level or effect of vinorelbine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unknown.